DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Meningioma. The EFO term Meningioma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Meningioma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

SE Dobbins, P Broderick, B Melin, M Feychting, C Johansen, U Andersson, T Brännström, J Schramm, B Olver, A Lloyd, YP Ma, FJ Hosking, S Lönn, A Ahlbom, R Henriksson, MJ Schoemaker, SJ Hepworth, P Hoffmann, TW Mühleisen, MM Nöthen, S Moebus, L Eisele, M Kosteljanetz, K Muir, A Swerdlow, M Simon, RS Houlston

TITLE:

Common variation at 10p12.31 near MLLT10 influences meningioma risk.

JOURNAL:

Nature genetics Jul 2011, Vol 43, pp. 825-7

ABSTRACT:

To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of the genetic basis of meningioma development. PUBMED: 21804547
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