DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Myocardial infarction. The EFO term myocardial infarction was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: myocardial infarction

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

A Helgadottir, G Thorleifsson, A Manolescu, S Gretarsdottir, T Blondal, A Jonasdottir, A Jonasdottir, A Sigurdsson, A Baker, A Palsson, G Masson, DF Gudbjartsson, KP Magnusson, K Andersen, AI Levey, VM Backman, S Matthiasdottir, T Jonsdottir, S Palsson, H Einarsdottir, S Gunnarsdottir, A Gylfason, V Vaccarino, WC Hooper, MP Reilly, CB Granger, H Austin, DJ Rader, SH Shah, AA Quyyumi, JR Gulcher, G Thorgeirsson, U Thorsteinsdottir, A Kong, K Stefansson

TITLE:

A common variant on chromosome 9p21 affects the risk of myocardial infarction.

JOURNAL:

Science (New York, N.Y.) Jun 2007, Vol 316, pp. 1491-3

ABSTRACT:

The global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association between myocardial infarction (MI) and a common sequence variant on chromosome 9p21. This study included a total of 4587 cases and 12,767 controls. The identified variant, adjacent to the tumor suppressor genes CDKN2A and CDKN2B, was associated with the disease with high significance. Approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardial infarction is 1.64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases. PUBMED: 17478679
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