DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Interstitial lung disease. The EFO term interstitial lung disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: interstitial lung disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

TE Fingerlin, E Murphy, W Zhang, AL Peljto, KK Brown, MP Steele, JE Loyd, GP Cosgrove, D Lynch, S Groshong, HR Collard, PJ Wolters, WZ Bradford, K Kossen, SD Seiwert, RM du Bois, CK Garcia, MS Devine, G Gudmundsson, HJ Isaksson, N Kaminski, Y Zhang, KF Gibson, LH Lancaster, JD Cogan, WR Mason, TM Maher, PL Molyneaux, AU Wells, MF Moffatt, M Selman, A Pardo, DS Kim, JD Crapo, BJ Make, EA Regan, DS Walek, JJ Daniel, Y Kamatani, D Zelenika, K Smith, D McKean, BS Pedersen, J Talbert, RN Kidd, CR Markin, KB Beckman, M Lathrop, MI Schwarz, DA Schwartz

TITLE:

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.

JOURNAL:

Nature genetics Jun 2013, Vol 45, pp. 613-20

ABSTRACT:

We performed a genome-wide association study of non-Hispanic, white individuals with fibrotic idiopathic interstitial pneumonias (IIPs; n = 1,616) and controls (n = 4,683), with follow-up replication analyses in 876 cases and 1,890 controls. We confirmed association with TERT at 5p15, MUC5B at 11p15 and the 3q26 region near TERC, and we identified seven newly associated loci (Pmeta = 2.4 × 10(-8) to 1.1 × 10(-19)), including FAM13A (4q22), DSP (6p24), OBFC1 (10q24), ATP11A (13q34), DPP9 (19p13) and chromosomal regions 7q22 and 15q14-15. Our results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs. PUBMED: 23583980
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