DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Rheumatoid arthritis. The EFO term rheumatoid arthritis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: rheumatoid arthritis

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

RM Plenge, M Seielstad, L Padyukov, AT Lee, EF Remmers, B Ding, A Liew, H Khalili, A Chandrasekaran, LR Davies, W Li, AK Tan, C Bonnard, RT Ong, A Thalamuthu, S Pettersson, C Liu, C Tian, WV Chen, JP Carulli, EM Beckman, D Altshuler, L Alfredsson, LA Criswell, CI Amos, MF Seldin, DL Kastner, L Klareskog, PK Gregersen

TITLE:

TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.

JOURNAL:

The New England journal of medicine Sep 2007, Vol 357, pp. 1199-209

ABSTRACT:

Rheumatoid arthritis has a complex mode of inheritance. Although HLA-DRB1 and PTPN22 are well-established susceptibility loci, other genes that confer a modest level of risk have been identified recently. We carried out a genomewide association analysis to identify additional genetic loci associated with an increased risk of rheumatoid arthritis. PUBMED: 17804836
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