DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Allergic sensitization. The EFO term allergic sensitization measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: allergic sensitization measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

K Bønnelykke, MC Matheson, TH Pers, R Granell, DP Strachan, AC Alves, A Linneberg, JA Curtin, NM Warrington, M Standl, M Kerkhof, I Jonsdottir, BK Bukvic, M Kaakinen, P Sleimann, G Thorleifsson, U Thorsteinsdottir, K Schramm, S Baltic, E Kreiner-Møller, A Simpson, B St Pourcain, L Coin, J Hui, EH Walters, CM Tiesler, DL Duffy, G Jones, SM Ring, WL McArdle, L Price, CF Robertson, J Pekkanen, CS Tang, E Thiering, GW Montgomery, AL Hartikainen, SC Dharmage, LL Husemoen, C Herder, JP Kemp, P Elliot, A James, M Waldenberger, MJ Abramson, BP Fairfax, JC Knight, R Gupta, PJ Thompson, P Holt, P Sly, JN Hirschhorn, M Blekic, S Weidinger, H Hakonarsson, K Stefansson, J Heinrich, DS Postma, A Custovic, CE Pennell, MR Jarvelin, GH Koppelman, N Timpson, MA Ferreira, H Bisgaard, AJ Henderson

TITLE:

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.

JOURNAL:

Nature genetics Aug 2013, Vol 45, pp. 902-6

ABSTRACT:

Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease. PUBMED: 23817571
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