DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Prostate cancer. The EFO term prostate carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: prostate carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

AA Al Olama, Z Kote-Jarai, SI Berndt, DV Conti, F Schumacher, Y Han, S Benlloch, DJ Hazelett, Z Wang, E Saunders, D Leongamornlert, S Lindstrom, S Jugurnauth-Little, T Dadaev, M Tymrakiewicz, DO Stram, K Rand, P Wan, A Stram, X Sheng, LC Pooler, K Park, L Xia, J Tyrer, LN Kolonel, L Le Marchand, RN Hoover, MJ Machiela, M Yeager, L Burdette, CC Chung, A Hutchinson, K Yu, C Goh, M Ahmed, K Govindasami, M Guy, TL Tammela, A Auvinen, T Wahlfors, J Schleutker, T Visakorpi, KA Leinonen, J Xu, M Aly, J Donovan, RC Travis, TJ Key, A Siddiq, F Canzian, KT Khaw, A Takahashi, M Kubo, P Pharoah, N Pashayan, M Weischer, BG Nordestgaard, SF Nielsen, P Klarskov, MA Røder, P Iversen, SN Thibodeau, SK McDonnell, DJ Schaid, JL Stanford, S Kolb, S Holt, B Knudsen, AH Coll, SM Gapstur, WR Diver, VL Stevens, C Maier, M Luedeke, K Herkommer, AE Rinckleb, SS Strom, C Pettaway, ED Yeboah, Y Tettey, RB Biritwum, AA Adjei, E Tay, A Truelove, S Niwa, AP Chokkalingam, L Cannon-Albright, C Cybulski, D Wokołorczyk, W Kluźniak, J Park, T Sellers, HY Lin, WB Isaacs, AW Partin, H Brenner, AK Dieffenbach, C Stegmaier, C Chen, EL Giovannucci, J Ma, M Stampfer, KL Penney, L Mucci, EM John, SA Ingles, RA Kittles, AB Murphy, H Pandha, A Michael, AM Kierzek, W Blot, LB Signorello, W Zheng, D Albanes, J Virtamo, S Weinstein, B Nemesure, J Carpten, C Leske, SY Wu, A Hennis, AS Kibel, BA Rybicki, C Neslund-Dudas, AW Hsing, L Chu, PJ Goodman, EA Klein, SL Zheng, J Batra, J Clements, A Spurdle, MR Teixeira, P Paulo, S Maia, C Slavov, R Kaneva, V Mitev, JS Witte, G Casey, EM Gillanders, D Seminara, E Riboli, FC Hamdy, GA Coetzee, Q Li, ML Freedman, DJ Hunter, K Muir, H Gronberg, DE Neal, M Southey, GG Giles, G Severi, MB Cook, H Nakagawa, F Wiklund, P Kraft, SJ Chanock, BE Henderson, DF Easton, RA Eeles, CA Haiman

TITLE:

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.

JOURNAL:

Nature genetics Oct 2014, Vol 46, pp. 1103-9

ABSTRACT:

Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease. PUBMED: 25217961
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