DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Colorectal cancer. The EFO term colorectal cancer was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: colorectal cancer

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

IP Tomlinson, E Webb, L Carvajal-Carmona, P Broderick, K Howarth, AM Pittman, S Spain, S Lubbe, A Walther, K Sullivan, E Jaeger, S Fielding, A Rowan, J Vijayakrishnan, E Domingo, I Chandler, Z Kemp, M Qureshi, SM Farrington, A Tenesa, JG Prendergast, RA Barnetson, S Penegar, E Barclay, W Wood, L Martin, M Gorman, H Thomas, J Peto, DT Bishop, R Gray, ER Maher, A Lucassen, D Kerr, DG Evans, C Schafmayer, S Buch, H Völzke, J Hampe, S Schreiber, U John, T Koessler, P Pharoah, T van Wezel, H Morreau, JT Wijnen, JL Hopper, MC Southey, GG Giles, G Severi, S Castellví-Bel, C Ruiz-Ponte, A Carracedo, A Castells, A Försti, K Hemminki, P Vodicka, A Naccarati, L Lipton, JW Ho, KK Cheng, PC Sham, J Luk, JA Agúndez, JM Ladero, M de la Hoya, T Caldés, I Niittymäki, S Tuupanen, A Karhu, L Aaltonen, JB Cazier, H Campbell, MG Dunlop, RS Houlston

TITLE:

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.

JOURNAL:

Nature genetics May 2008, Vol 40, pp. 623-30

ABSTRACT:

To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10(-4) in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward to phase 4 genotyping (10,731 CRC cases and 10,961 controls from eight centers). In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 x 10(-13) overall; P = 6.9 x 10(-12) replication), and rs16892766, at 8q23.3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition. PUBMED: 18372905
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