DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Chronic lymphocytic leukemia. The EFO term chronic lymphocytic leukemia was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: chronic lymphocytic leukemia

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

MC Di Bernardo, D Crowther-Swanepoel, P Broderick, E Webb, G Sellick, R Wild, K Sullivan, J Vijayakrishnan, Y Wang, AM Pittman, NJ Sunter, AG Hall, MJ Dyer, E Matutes, C Dearden, T Mainou-Fowler, GH Jackson, G Summerfield, RJ Harris, AR Pettitt, P Hillmen, DJ Allsup, JR Bailey, G Pratt, C Pepper, C Fegan, JM Allan, D Catovsky, RS Houlston

TITLE:

A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.

JOURNAL:

Nature genetics Oct 2008, Vol 40, pp. 1204-10

ABSTRACT:

We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 cases and 3,115 controls. We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 x 10(-10)), 2q37.1 (rs13397985, SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1 (rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and 19q13.32 (rs11083846, PRKD2; P = 3.96 x 10(-9)). These data provide the first evidence for the existence of common, low-penetrance susceptibility to a hematological malignancy and new insights into disease causation in CLL. PUBMED: 18758461
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