DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Blood pressure. The EFO term diastolic blood pressure was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: diastolic blood pressure

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

N Franceschini, E Fox, Z Zhang, TL Edwards, MA Nalls, YJ Sung, BO Tayo, YV Sun, O Gottesman, A Adeyemo, AD Johnson, JH Young, K Rice, Q Duan, F Chen, Y Li, H Tang, M Fornage, KL Keene, JS Andrews, JA Smith, JD Faul, Z Guangfa, W Guo, Y Liu, SS Murray, SK Musani, S Srinivasan, DR Velez Edwards, H Wang, LC Becker, P Bovet, M Bochud, U Broeckel, M Burnier, C Carty, DI Chasman, G Ehret, WM Chen, G Chen, W Chen, J Ding, AW Dreisbach, MK Evans, X Guo, ME Garcia, R Jensen, MF Keller, G Lettre, V Lotay, LW Martin, JH Moore, AC Morrison, TH Mosley, A Ogunniyi, W Palmas, G Papanicolaou, A Penman, JF Polak, PM Ridker, B Salako, AB Singleton, D Shriner, KD Taylor, R Vasan, K Wiggins, SM Williams, LR Yanek, W Zhao, AB Zonderman, DM Becker, G Berenson, E Boerwinkle, E Bottinger, M Cushman, C Eaton, F Nyberg, G Heiss, JN Hirschhron, VJ Howard, KJ Karczewsk, MB Lanktree, K Liu, Y Liu, R Loos, K Margolis, M Snyder, BM Psaty, NJ Schork, DR Weir, CN Rotimi, MM Sale, T Harris, SL Kardia, SC Hunt, D Arnett, S Redline, RS Cooper, NJ Risch, DC Rao, JI Rotter, A Chakravarti, AP Reiner, D Levy, BJ Keating, X Zhu

TITLE:

Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.

JOURNAL:

American journal of human genetics Sep 2013, Vol 93, pp. 545-54

ABSTRACT:

High blood pressure (BP) is more prevalent and contributes to more severe manifestations of cardiovascular disease (CVD) in African Americans than in any other United States ethnic group. Several small African-ancestry (AA) BP genome-wide association studies (GWASs) have been published, but their findings have failed to replicate to date. We report on a large AA BP GWAS meta-analysis that includes 29,378 individuals from 19 discovery cohorts and subsequent replication in additional samples of AA (n = 10,386), European ancestry (EA) (n = 69,395), and East Asian ancestry (n = 19,601). Five loci (EVX1-HOXA, ULK4, RSPO3, PLEKHG1, and SOX6) reached genome-wide significance (p < 1.0 × 10(-8)) for either systolic or diastolic BP in a transethnic meta-analysis after correction for multiple testing. Three of these BP loci (EVX1-HOXA, RSPO3, and PLEKHG1) lack previous associations with BP. We also identified one independent signal in a known BP locus (SOX6) and provide evidence for fine mapping in four additional validated BP loci. We also demonstrate that validated EA BP GWAS loci, considered jointly, show significant effects in AA samples. Consequently, these findings suggest that BP loci might have universal effects across studied populations, demonstrating that multiethnic samples are an essential component in identifying, fine mapping, and understanding their trait variability. PUBMED: 23972371
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