DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was IFN-related cytopenia. The EFO term Chronic Hepatitis C infection was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Chronic Hepatitis C infection

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

AJ Thompson, PJ Clark, A Singh, D Ge, J Fellay, M Zhu, Q Zhu, TJ Urban, K Patel, HL Tillmann, S Naggie, NH Afdhal, IM Jacobson, R Esteban, F Poordad, EJ Lawitz, J McCone, ML Shiffman, GW Galler, JW King, PY Kwo, KV Shianna, S Noviello, LD Pedicone, CA Brass, JK Albrecht, MS Sulkowski, DB Goldstein, JG McHutchison, AJ Muir

TITLE:

Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients.

JOURNAL:

Journal of hepatology Feb 2012, Vol 56, pp. 313-9

ABSTRACT:

Interferon-alfa (IFN)-related cytopenias are common and may be dose-limiting. We performed a genome wide association study on a well-characterized genotype 1 HCV cohort to identify genetic determinants of peginterferon-α (pegIFN)-related thrombocytopenia, neutropenia, and leukopenia. PUBMED: 21703177
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