DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Esophageal squamous cell carcinoma. The EFO term esophageal squamous cell carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: esophageal squamous cell carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

C Wu, Z Wang, X Song, XS Feng, CC Abnet, J He, N Hu, XB Zuo, W Tan, Q Zhan, Z Hu, Z He, W Jia, Y Zhou, K Yu, XO Shu, JM Yuan, W Zheng, XK Zhao, SG Gao, ZQ Yuan, FY Zhou, ZM Fan, JL Cui, HL Lin, XN Han, B Li, X Chen, SM Dawsey, L Liao, MP Lee, T Ding, YL Qiao, Z Liu, Y Liu, D Yu, J Chang, L Wei, YT Gao, WP Koh, YB Xiang, ZZ Tang, JH Fan, JJ Han, SL Zhou, P Zhang, DY Zhang, Y Yuan, Y Huang, C Liu, K Zhai, Y Qiao, G Jin, C Guo, J Fu, X Miao, C Lu, H Yang, C Wang, WA Wheeler, M Gail, M Yeager, J Yuenger, ET Guo, AL Li, W Zhang, XM Li, LD Sun, BG Ma, Y Li, S Tang, XQ Peng, J Liu, A Hutchinson, K Jacobs, C Giffen, L Burdette, JF Fraumeni, H Shen, Y Ke, Y Zeng, T Wu, P Kraft, CC Chung, MA Tucker, ZC Hou, YL Liu, YL Hu, Y Liu, L Wang, G Yuan, LS Chen, X Liu, T Ma, H Meng, L Sun, XM Li, XM Li, JW Ku, YF Zhou, LQ Yang, Z Wang, Y Li, Q Qige, WJ Yang, GY Lei, LQ Chen, EM Li, L Yuan, WB Yue, R Wang, LW Wang, XP Fan, FH Zhu, WX Zhao, YM Mao, M Zhang, GL Xing, JL Li, M Han, JL Ren, B Liu, SW Ren, QP Kong, F Li, I Sheyhidin, W Wei, YR Zhang, CW Feng, J Wang, YH Yang, HZ Hao, QD Bao, BC Liu, AQ Wu, D Xie, WC Yang, L Wang, XH Zhao, SQ Chen, JY Hong, XJ Zhang, ND Freedman, AM Goldstein, D Lin, PR Taylor, LD Wang, SJ Chanock

TITLE:

Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.

JOURNAL:

Nature genetics Sep 2014, Vol 46, pp. 1001-6

ABSTRACT:

We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.85, 95% confidence interval (CI) = 0.82-0.88; P = 7.72 × 10(-20)) and rs1642764 at 17p13.1 (per-allele OR = 0.88, 95% CI = 0.85-0.91; P = 3.10 × 10(-13)). rs7447927 is a synonymous SNP in TMEM173, and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21.32 (rs35597309) achieved genome-wide significance in the two populations at highest risk for ESSC (OR = 1.33, 95% CI = 1.22-1.46; P = 1.99 × 10(-10)). Our joint analysis identifies new ESCC susceptibility loci overall as well as a new locus unique to the population in the Taihang Mountain region at high risk of ESCC. PUBMED: 25129146
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