DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Tourette syndrome. The EFO term Tourette syndrome was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Tourette syndrome

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JM Scharf, D Yu, CA Mathews, BM Neale, SE Stewart, JA Fagerness, P Evans, E Gamazon, CK Edlund, SK Service, A Tikhomirov, L Osiecki, C Illmann, A Pluzhnikov, A Konkashbaev, LK Davis, B Han, J Crane, P Moorjani, AT Crenshaw, MA Parkin, VI Reus, TL Lowe, M Rangel-Lugo, S Chouinard, Y Dion, S Girard, DC Cath, JH Smit, RA King, TV Fernandez, JF Leckman, KK Kidd, JR Kidd, AJ Pakstis, MW State, LD Herrera, R Romero, E Fournier, P Sandor, CL Barr, N Phan, V Gross-Tsur, F Benarroch, Y Pollak, CL Budman, RD Bruun, G Erenberg, AL Naarden, PC Lee, N Weiss, B Kremeyer, GB Berrío, DD Campbell, JC Cardona Silgado, WC Ochoa, SC Mesa Restrepo, H Muller, AV Valencia Duarte, GJ Lyon, M Leppert, J Morgan, R Weiss, MA Grados, K Anderson, S Davarya, H Singer, J Walkup, J Jankovic, JA Tischfield, GA Heiman, DL Gilbert, PJ Hoekstra, MM Robertson, R Kurlan, C Liu, JR Gibbs, A Singleton, J Hardy, E Strengman, RA Ophoff, M Wagner, R Moessner, DB Mirel, D Posthuma, C Sabatti, E Eskin, DV Conti, JA Knowles, A Ruiz-Linares, GA Rouleau, S Purcell, P Heutink, BA Oostra, WM McMahon, NB Freimer, NJ Cox, DL Pauls

TITLE:

Genome-wide association study of Tourette's syndrome.

JOURNAL:

Molecular psychiatry Jun 2013, Vol 18, pp. 721-8

ABSTRACT:

Tourette's syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association study (GWAS) of TS in 1285 cases and 4964 ancestry-matched controls of European ancestry, including two European-derived population isolates, Ashkenazi Jews from North America and Israel and French Canadians from Quebec, Canada. In a primary meta-analysis of GWAS data from these European ancestry samples, no markers achieved a genome-wide threshold of significance (P<5 × 10(-8)); the top signal was found in rs7868992 on chromosome 9q32 within COL27A1 (P=1.85 × 10(-6)). A secondary analysis including an additional 211 cases and 285 controls from two closely related Latin American population isolates from the Central Valley of Costa Rica and Antioquia, Colombia also identified rs7868992 as the top signal (P=3.6 × 10(-7) for the combined sample of 1496 cases and 5249 controls following imputation with 1000 Genomes data). This study lays the groundwork for the eventual identification of common TS susceptibility variants in larger cohorts and helps to provide a more complete understanding of the full genetic architecture of this disorder. PUBMED: 22889924
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