DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Obsessive-compulsive disorder. The EFO term obsessive-compulsive disorder was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: obsessive-compulsive disorder

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

SE Stewart, D Yu, JM Scharf, BM Neale, JA Fagerness, CA Mathews, PD Arnold, PD Evans, ER Gamazon, LK Davis, L Osiecki, L McGrath, S Haddad, J Crane, D Hezel, C Illman, C Mayerfeld, A Konkashbaev, C Liu, A Pluzhnikov, A Tikhomirov, CK Edlund, SL Rauch, R Moessner, P Falkai, W Maier, S Ruhrmann, HJ Grabe, L Lennertz, M Wagner, L Bellodi, MC Cavallini, MA Richter, EH Cook, JL Kennedy, D Rosenberg, DJ Stein, SM Hemmings, C Lochner, A Azzam, DA Chavira, E Fournier, H Garrido, B Sheppard, P Umaña, DL Murphy, JR Wendland, J Veenstra-VanderWeele, D Denys, R Blom, D Deforce, F Van Nieuwerburgh, HG Westenberg, S Walitza, K Egberts, T Renner, EC Miguel, C Cappi, AG Hounie, M Conceição do Rosário, AS Sampaio, H Vallada, H Nicolini, N Lanzagorta, B Camarena, R Delorme, M Leboyer, CN Pato, MT Pato, E Voyiaziakis, P Heutink, DC Cath, D Posthuma, JH Smit, J Samuels, OJ Bienvenu, B Cullen, AJ Fyer, MA Grados, BD Greenberg, JT McCracken, MA Riddle, Y Wang, V Coric, JF Leckman, M Bloch, C Pittenger, V Eapen, DW Black, RA Ophoff, E Strengman, D Cusi, M Turiel, F Frau, F Macciardi, JR Gibbs, MR Cookson, A Singleton, J Hardy, AT Crenshaw, MA Parkin, DB Mirel, DV Conti, S Purcell, G Nestadt, GL Hanna, MA Jenike, JA Knowles, N Cox, DL Pauls

TITLE:

Genome-wide association study of obsessive-compulsive disorder.

JOURNAL:

Molecular psychiatry Jul 2013, Vol 18, pp. 788-98

ABSTRACT:

Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness with complex genetic etiology. The International OCD Foundation Genetics Collaborative (IOCDF-GC) is a multi-national collaboration established to discover the genetic variation predisposing to OCD. A set of individuals affected with DSM-IV OCD, a subset of their parents, and unselected controls, were genotyped with several different Illumina SNP microarrays. After extensive data cleaning, 1465 cases, 5557 ancestry-matched controls and 400 complete trios remained, with a common set of 469,410 autosomal and 9657 X-chromosome single nucleotide polymorphisms (SNPs). Ancestry-stratified case-control association analyses were conducted for three genetically-defined subpopulations and combined in two meta-analyses, with and without the trio-based analysis. In the case-control analysis, the lowest two P-values were located within DLGAP1 (P=2.49 × 10(-6) and P=3.44 × 10(-6)), a member of the neuronal postsynaptic density complex. In the trio analysis, rs6131295, near BTBD3, exceeded the genome-wide significance threshold with a P-value=3.84 × 10(-8). However, when trios were meta-analyzed with the case-control samples, the P-value for this variant was 3.62 × 10(-5), losing genome-wide significance. Although no SNPs were identified to be associated with OCD at a genome-wide significant level in the combined trio-case-control sample, a significant enrichment of methylation QTLs (P<0.001) and frontal lobe expression quantitative trait loci (eQTLs) (P=0.001) was observed within the top-ranked SNPs (P<0.01) from the trio-case-control analysis, suggesting these top signals may have a broad role in gene expression in the brain, and possibly in the etiology of OCD. PUBMED: 22889921
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