DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Breast cancer (male). The EFO term breast carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: breast carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

N Orr, A Lemnrau, R Cooke, O Fletcher, K Tomczyk, M Jones, N Johnson, CJ Lord, C Mitsopoulos, M Zvelebil, SS McDade, G Buck, C Blancher, AH Trainer, PA James, SE Bojesen, S Bokmand, H Nevanlinna, J Mattson, E Friedman, Y Laitman, D Palli, G Masala, I Zanna, L Ottini, G Giannini, A Hollestelle, AM Ouweland, S Novaković, M Krajc, M Gago-Dominguez, JE Castelao, H Olsson, I Hedenfalk, DF Easton, PD Pharoah, AM Dunning, DT Bishop, SL Neuhausen, L Steele, RS Houlston, M Garcia-Closas, A Ashworth, AJ Swerdlow

TITLE:

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.

JOURNAL:

Nature genetics Nov 2012, Vol 44, pp. 1182-4

ABSTRACT:

We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10(-15); OR = 1.50). PUBMED: 23001122
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