GeneSet Information

Tier I GS268537 • GWAS Catalog Data for body mass index in Up to 123,865 European ancestry individuals

DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Body mass index. The EFO term body mass index was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: body mass index

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

EK Speliotes, CJ Willer, SI Berndt, KL Monda, G Thorleifsson, AU Jackson, H Lango Allen, CM Lindgren, J Luan, R Mägi, JC Randall, S Vedantam, TW Winkler, L Qi, T Workalemahu, IM Heid, V Steinthorsdottir, HM Stringham, MN Weedon, E Wheeler, AR Wood, T Ferreira, RJ Weyant, AV Segrè, K Estrada, L Liang, J Nemesh, JH Park, S Gustafsson, TO Kilpeläinen, J Yang, N Bouatia-Naji, T Esko, MF Feitosa, Z Kutalik, M Mangino, S Raychaudhuri, A Scherag, AV Smith, R Welch, JH Zhao, KK Aben, DM Absher, N Amin, AL Dixon, E Fisher, NL Glazer, ME Goddard, NL Heard-Costa, V Hoesel, JJ Hottenga, A Johansson, T Johnson, S Ketkar, C Lamina, S Li, MF Moffatt, RH Myers, N Narisu, JR Perry, MJ Peters, M Preuss, S Ripatti, F Rivadeneira, C Sandholt, LJ Scott, NJ Timpson, JP Tyrer, S van Wingerden, RM Watanabe, CC White, F Wiklund, C Barlassina, DI Chasman, MN Cooper, JO Jansson, RW Lawrence, N Pellikka, I Prokopenko, J Shi, E Thiering, H Alavere, MT Alibrandi, P Almgren, AM Arnold, T Aspelund, LD Atwood, B Balkau, AJ Balmforth, AJ Bennett, Y Ben-Shlomo, RN Bergman, S Bergmann, H Biebermann, AI Blakemore, T Boes, LL Bonnycastle, SR Bornstein, MJ Brown, TA Buchanan, F Busonero, H Campbell, FP Cappuccio, C Cavalcanti-Proença, YD Chen, CM Chen, PS Chines, R Clarke, L Coin, J Connell, IN Day, M den Heijer, J Duan, S Ebrahim, P Elliott, R Elosua, G Eiriksdottir, MR Erdos, JG Eriksson, MF Facheris, SB Felix, P Fischer-Posovszky, AR Folsom, N Friedrich, NB Freimer, M Fu, S Gaget, PV Gejman, EJ Geus, C Gieger, AP Gjesing, A Goel, P Goyette, H Grallert, J Grässler, DM Greenawalt, CJ Groves, V Gudnason, C Guiducci, AL Hartikainen, N Hassanali, AS Hall, AS Havulinna, C Hayward, AC Heath, C Hengstenberg, AA Hicks, A Hinney, A Hofman, G Homuth, J Hui, W Igl, C Iribarren, B Isomaa, KB Jacobs, I Jarick, E Jewell, U John, T Jørgensen, P Jousilahti, A Jula, M Kaakinen, E Kajantie, LM Kaplan, S Kathiresan, J Kettunen, L Kinnunen, JW Knowles, I Kolcic, IR König, S Koskinen, P Kovacs, J Kuusisto, P Kraft, K Kvaløy, J Laitinen, O Lantieri, C Lanzani, LJ Launer, C Lecoeur, T Lehtimäki, G Lettre, J Liu, ML Lokki, M Lorentzon, RN Luben, B Ludwig, P Manunta, D Marek, M Marre, NG Martin, WL McArdle, A McCarthy, B McKnight, T Meitinger, O Melander, D Meyre, K Midthjell, GW Montgomery, MA Morken, AP Morris, R Mulic, JS Ngwa, M Nelis, MJ Neville, DR Nyholt, CJ O'Donnell, S O'Rahilly, KK Ong, B Oostra, G Paré, AN Parker, M Perola, I Pichler, KH Pietiläinen, CG Platou, O Polasek, A Pouta, S Rafelt, O Raitakari, NW Rayner, M Ridderstråle, W Rief, A Ruokonen, NR Robertson, P Rzehak, V Salomaa, AR Sanders, MS Sandhu, S Sanna, J Saramies, MJ Savolainen, S Scherag, S Schipf, S Schreiber, H Schunkert, K Silander, J Sinisalo, DS Siscovick, JH Smit, N Soranzo, U Sovio, J Stephens, I Surakka, AJ Swift, ML Tammesoo, JC Tardif, M Teder-Laving, TM Teslovich, JR Thompson, B Thomson, A Tönjes, T Tuomi, JB van Meurs, GJ van Ommen, V Vatin, J Viikari, S Visvikis-Siest, V Vitart, CI Vogel, BF Voight, LL Waite, H Wallaschofski, GB Walters, E Widen, S Wiegand, SH Wild, G Willemsen, DR Witte, JC Witteman, J Xu, Q Zhang, L Zgaga, A Ziegler, P Zitting, JP Beilby, IS Farooqi, J Hebebrand, HV Huikuri, AL James, M Kähönen, DF Levinson, F Macciardi, MS Nieminen, C Ohlsson, LJ Palmer, PM Ridker, M Stumvoll, JS Beckmann, H Boeing, E Boerwinkle, DI Boomsma, MJ Caulfield, SJ Chanock, FS Collins, LA Cupples, GD Smith, J Erdmann, P Froguel, H Grönberg, U Gyllensten, P Hall, T Hansen, TB Harris, AT Hattersley, RB Hayes, J Heinrich, FB Hu, K Hveem, T Illig, MR Jarvelin, J Kaprio, F Karpe, KT Khaw, LA Kiemeney, H Krude, M Laakso, DA Lawlor, A Metspalu, PB Munroe, WH Ouwehand, O Pedersen, BW Penninx, A Peters, PP Pramstaller, T Quertermous, T Reinehr, A Rissanen, I Rudan, NJ Samani, PE Schwarz, AR Shuldiner, TD Spector, J Tuomilehto, M Uda, A Uitterlinden, TT Valle, M Wabitsch, G Waeber, NJ Wareham, H Watkins, JF Wilson, AF Wright, MC Zillikens, N Chatterjee, SA McCarroll, S Purcell, EE Schadt, PM Visscher, TL Assimes, IB Borecki, P Deloukas, CS Fox, LC Groop, T Haritunians, DJ Hunter, RC Kaplan, KL Mohlke, JR O'Connell, L Peltonen, D Schlessinger, DP Strachan, CM van Duijn, HE Wichmann, TM Frayling, U Thorsteinsdottir, GR Abecasis, I Barroso, M Boehnke, K Stefansson, KE North, MI McCarthy, JN Hirschhorn, E Ingelsson, RJ Loos

TITLE:

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

JOURNAL:

Nature genetics Nov 2010, Vol 42, pp. 937-48

ABSTRACT:

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation. PUBMED: 20935630
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Annotation Information

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body mass index (EFO:0004340)

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