DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was AR-C124910XX levels in individuals with acute coronary syndromes treated with ticagrelor. The EFO term AR-C124910XX measurement, acute coronary syndrome was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: AR-C124910XX measurement, acute coronary syndrome

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

C Varenhorst, N Eriksson, Å Johansson, BJ Barratt, E Hagström, A Åkerblom, AC Syvänen, RC Becker, SK James, HA Katus, S Husted, PG Steg, A Siegbahn, D Voora, R Teng, RF Storey, L Wallentin

TITLE:

Effect of genetic variations on ticagrelor plasma levels and clinical outcomes.

JOURNAL:

European heart journal Aug 2015, Vol 36, pp. 1901-12

ABSTRACT:

Ticagrelor, a direct-acting P2Y12-receptor antagonist, is rapidly absorbed and partly metabolized to the major metabolite AR-C124910XX (ARC). To identify single-nucleotide polymorphisms (SNPs) associated with pharmacokinetics of ticagrelor and clinical outcomes, we performed a genome-wide association study (GWAS) in patients treated with ticagrelor in the PLATO trial. PUBMED: 25935875
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