DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Amyotrophic lateral sclerosis. The EFO term amyotrophic lateral sclerosis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: amyotrophic lateral sclerosis

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

MA van Es, PW van Vught, HM Blauw, L Franke, CG Saris, L Van den Bosch, SW de Jong, V de Jong, F Baas, R van't Slot, R Lemmens, HJ Schelhaas, A Birve, K Sleegers, C Van Broeckhoven, JC Schymick, BJ Traynor, JH Wokke, C Wijmenga, W Robberecht, PM Andersen, JH Veldink, RA Ophoff, LH van den Berg

TITLE:

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.

JOURNAL:

Nature genetics Jan 2008, Vol 40, pp. 29-31

ABSTRACT:

We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies. PUBMED: 18084291
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