DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was LDL cholesterol. The EFO term low density lipoprotein cholesterol measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: low density lipoprotein cholesterol measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

R Burkhardt, EE Kenny, JK Lowe, A Birkeland, R Josowitz, M Noel, J Salit, JB Maller, I Pe'er, MJ Daly, D Altshuler, M Stoffel, JM Friedman, JL Breslow

TITLE:

Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.

JOURNAL:

Arteriosclerosis, thrombosis, and vascular biology Nov 2008, Vol 28, pp. 2078-84

ABSTRACT:

Background- Variation in LDL-cholesterol (LDL-C) among individuals is a complex genetic trait involving multiple genes and gene-environment interactions. PUBMED: 18802019
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