GeneSet Information

Tier I GS268505 • GWAS Catalog Data for coronary heart disease in 2,123 Korean ancestry cases, 3,591 Korean ancestry controls

DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Coronary heart disease. The EFO term coronary heart disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: coronary heart disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JY Lee, BS Lee, DJ Shin, K Woo Park, YA Shin, K Joong Kim, L Heo, J Young Lee, Y Kyoung Kim, Y Jin Kim, C Bum Hong, SH Lee, D Yoon, H Jung Ku, IY Oh, BJ Kim, J Lee, SJ Park, J Kim, HK Kawk, JE Lee, HK Park, JE Lee, HY Nam, HY Park, C Shin, M Yokota, H Asano, M Nakatochi, T Matsubara, H Kitajima, K Yamamoto, HL Kim, BG Han, MC Cho, Y Jang, HS Kim, J Euy Park, JY Lee

TITLE:

A genome-wide association study of a coronary artery disease risk variant.

JOURNAL:

Journal of human genetics Mar 2013, Vol 58, pp. 120-6

ABSTRACT:

Although over 30 common genetic susceptibility loci have been identified to be independently associated with coronary artery disease (CAD) risk through genome-wide association studies (GWAS), genetic risk variants reported to date explain only a small fraction of heritability. To identify novel susceptibility variants for CAD and confirm those previously identified in European population, GWAS and a replication study were performed in the Koreans and Japanese. In the discovery stage, we genotyped 2123 cases and 3591 controls with 521 786 SNPs using the Affymetrix SNP Array 6.0 chips in Korean. In the replication, direct genotyping was performed using 3052 cases and 4976 controls from the KItaNagoya Genome study of Japan with 14 selected SNPs. To maximize the coverage of the genome, imputation was performed based on 1000 Genome JPT+CHB and 5.1 million SNPs were retained. CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans. From GWAS and a replication, SNP rs3782889 showed a strong association (combined P=3.95 × 10(-14)), although the association of SNP rs3782889 doesn't remain statistically significant after adjusting for SNP rs11066015 (proxy SNP with BRAP (r(2)=1)). But new possible CAD-associated variant was observed for rs9508025 (FLT1), even though its statistical significance did marginally reach at the genome-wide a significance level (combined P=6.07 × 10(-7)). This study shows that three CAD susceptibility loci, which were previously identified in European can be directly replicated in Koreans and also provides additional evidences implicating suggestive loci as risk variants for CAD in East Asian. PUBMED: 23364394
Find other GeneSets from this publication

Annotation Information

No sequence read archive data associated with this GeneSet.


coronary heart disease (EFO:0001645)

Gene List • 7 Genes

Uploaded As Gene Symbol Homology Score Priority LinkOuts Emphasis