DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Obesity. The EFO term obesity was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: obesity

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

D Meyre, J Delplanque, JC Chèvre, C Lecoeur, S Lobbens, S Gallina, E Durand, V Vatin, F Degraeve, C Proença, S Gaget, A Körner, P Kovacs, W Kiess, J Tichet, M Marre, AL Hartikainen, F Horber, N Potoczna, S Hercberg, C Levy-Marchal, F Pattou, B Heude, M Tauber, MI McCarthy, AI Blakemore, A Montpetit, C Polychronakos, J Weill, LJ Coin, J Asher, P Elliott, MR Järvelin, S Visvikis-Siest, B Balkau, R Sladek, D Balding, A Walley, C Dina, P Froguel

TITLE:

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.

JOURNAL:

Nature genetics Feb 2009, Vol 41, pp. 157-9

ABSTRACT:

We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)). PUBMED: 19151714
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