DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Migraine - clinic-based. The EFO term migraine disorder was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: migraine disorder

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

V Anttila, BS Winsvold, P Gormley, T Kurth, F Bettella, G McMahon, M Kallela, R Malik, B de Vries, G Terwindt, SE Medland, U Todt, WL McArdle, L Quaye, M Koiranen, MA Ikram, T Lehtimäki, AH Stam, L Ligthart, J Wedenoja, I Dunham, BM Neale, P Palta, E Hamalainen, M Schürks, LM Rose, JE Buring, PM Ridker, S Steinberg, H Stefansson, F Jakobsson, DA Lawlor, DM Evans, SM Ring, M Färkkilä, V Artto, MA Kaunisto, T Freilinger, J Schoenen, RR Frants, N Pelzer, CM Weller, R Zielman, AC Heath, PA Madden, GW Montgomery, NG Martin, G Borck, H Göbel, A Heinze, K Heinze-Kuhn, FM Williams, AL Hartikainen, A Pouta, J van den Ende, AG Uitterlinden, A Hofman, N Amin, JJ Hottenga, JM Vink, K Heikkilä, M Alexander, B Muller-Myhsok, S Schreiber, T Meitinger, HE Wichmann, A Aromaa, JG Eriksson, BJ Traynor, D Trabzuni, E Rossin, K Lage, SB Jacobs, JR Gibbs, E Birney, J Kaprio, BW Penninx, DI Boomsma, C van Duijn, O Raitakari, MR Jarvelin, JA Zwart, L Cherkas, DP Strachan, C Kubisch, MD Ferrari, AM van den Maagdenberg, M Dichgans, M Wessman, GD Smith, K Stefansson, MJ Daly, DR Nyholt, DI Chasman, A Palotie

TITLE:

Genome-wide meta-analysis identifies new susceptibility loci for migraine.

JOURNAL:

Nature genetics Aug 2013, Vol 45, pp. 912-7

ABSTRACT:

Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B. PUBMED: 23793025
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