DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Axial length. The EFO term axial length measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: axial length measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

M Miyake, K Yamashiro, Y Tabara, K Suda, S Morooka, H Nakanishi, CC Khor, P Chen, F Qiao, I Nakata, Y Akagi-Kurashige, N Gotoh, A Tsujikawa, A Meguro, S Kusuhara, O Polasek, C Hayward, AF Wright, H Campbell, AJ Richardson, M Schache, M Takeuchi, DA Mackey, AW Hewitt, G Cuellar, Y Shi, L Huang, Z Yang, KH Leung, PY Kao, MK Yap, SP Yip, M Moriyama, K Ohno-Matsui, N Mizuki, S MacGregor, V Vitart, T Aung, SM Saw, ES Tai, TY Wong, CY Cheng, PN Baird, R Yamada, F Matsuda, N Yoshimura

TITLE:

Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.

JOURNAL:

Nature communications Mar 2015, Vol 6, pp. 6689

ABSTRACT:

Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10(-13)) and corneal curvature (Pmeta=2.9 × 10(-40)) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta=1.13, Pmeta=0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia. PUBMED: 25823570
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