DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Bipolar disorder. The EFO term bipolar disorder was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: bipolar disorder

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

MA Ferreira, MC O'Donovan, YA Meng, IR Jones, DM Ruderfer, L Jones, J Fan, G Kirov, RH Perlis, EK Green, JW Smoller, D Grozeva, J Stone, I Nikolov, K Chambert, ML Hamshere, VL Nimgaonkar, V Moskvina, ME Thase, S Caesar, GS Sachs, J Franklin, K Gordon-Smith, KG Ardlie, SB Gabriel, C Fraser, B Blumenstiel, M Defelice, G Breen, M Gill, DW Morris, A Elkin, WJ Muir, KA McGhee, R Williamson, DJ MacIntyre, AW MacLean, CD St, M Robinson, M Van Beck, AC Pereira, R Kandaswamy, A McQuillin, DA Collier, NJ Bass, AH Young, J Lawrence, IN Ferrier, A Anjorin, A Farmer, D Curtis, EM Scolnick, P McGuffin, MJ Daly, AP Corvin, PA Holmans, DH Blackwood, HM Gurling, MJ Owen, SM Purcell, P Sklar, N Craddock

TITLE:

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

JOURNAL:

Nature genetics Sep 2008, Vol 40, pp. 1056-8

ABSTRACT:

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder. PUBMED: 18711365
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