DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Systemic lupus erythematosus. The EFO term systemic lupus erythematosus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: systemic lupus erythematosus

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

W Yang, H Tang, Y Zhang, X Tang, J Zhang, L Sun, J Yang, Y Cui, L Zhang, N Hirankarn, H Cheng, HF Pan, J Gao, TL Lee, Y Sheng, CS Lau, Y Li, TM Chan, X Yin, D Ying, Q Lu, AM Leung, X Zuo, X Chen, KL Tong, F Zhou, Q Diao, NK Tse, H Xie, CC Mok, F Hao, SN Wong, B Shi, KW Lee, Y Hui, MH Ho, B Liang, PP Lee, H Cui, Q Guo, BH Chung, X Pu, Q Liu, X Zhang, C Zhang, CY Chong, H Fang, RW Wong, Y Sun, MY Mok, XP Li, Y Avihingsanon, Z Zhai, P Rianthavorn, T Deekajorndej, K Suphapeetiporn, F Gao, V Shotelersuk, X Kang, SK Ying, L Zhang, WH Wong, D Zhu, SK Fung, F Zeng, WM Lai, CM Wong, IO Ng, MM Garcia-Barceló, SS Cherny, N Shen, PK Tam, PC Sham, DQ Ye, S Yang, X Zhang, YL Lau

TITLE:

Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.

JOURNAL:

American journal of human genetics Jan 2013, Vol 92, pp. 41-51

ABSTRACT:

Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with a strong genetic involvement and ethnic differences. Susceptibility genes identified so far only explain a small portion of the genetic heritability of SLE, suggesting that many more loci are yet to be uncovered for this disease. In this study, we performed a meta-analysis of genome-wide association studies on SLE in Chinese Han populations and followed up the findings by replication in four additional Asian cohorts with a total of 5,365 cases and 10,054 corresponding controls. We identified genetic variants in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with the disease. These findings point to potential roles of cell-cycle regulation, autophagy, and DNA demethylation in SLE pathogenesis. For the region involving TET3 and that involving CDKN1B, multiple independent SNPs were identified, highlighting a phenomenon that might partially explain the missing heritability of complex diseases. PUBMED: 23273568
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