DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Asthma (childhood onset). The EFO term childhood onset asthma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: childhood onset asthma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

K Bønnelykke, P Sleiman, K Nielsen, E Kreiner-Møller, JM Mercader, D Belgrave, HT den Dekker, A Husby, A Sevelsted, G Faura-Tellez, LJ Mortensen, L Paternoster, R Flaaten, A Mølgaard, DE Smart, PF Thomsen, MA Rasmussen, S Bonàs-Guarch, C Holst, EA Nohr, R Yadav, ME March, T Blicher, PM Lackie, VW Jaddoe, A Simpson, JW Holloway, L Duijts, A Custovic, DE Davies, D Torrents, R Gupta, MV Hollegaard, DM Hougaard, H Hakonarson, H Bisgaard

TITLE:

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.

JOURNAL:

Nature genetics Jan 2014, Vol 46, pp. 51-5

ABSTRACT:

Asthma exacerbations are among the most frequent causes of hospitalization during childhood, but the underlying mechanisms are poorly understood. We performed a genome-wide association study of a specific asthma phenotype characterized by recurrent, severe exacerbations occurring between 2 and 6 years of age in a total of 1,173 cases and 2,522 controls. Cases were identified from national health registries of hospitalization, and DNA was obtained from the Danish Neonatal Screening Biobank. We identified five loci with genome-wide significant association. Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma. We also obtained strong evidence for a new susceptibility gene, CDHR3 (encoding cadherin-related family member 3), which is highly expressed in airway epithelium. These results demonstrate the strength of applying specific phenotyping in the search for asthma susceptibility genes. PUBMED: 24241537
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