DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Very long-chain saturated fatty acid levels (fatty acid 24:0). The EFO term very long-chain saturated fatty acid measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: very long-chain saturated fatty acid measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

RN Lemaitre, IB King, EK Kabagambe, JH Wu, B McKnight, A Manichaikul, W Guan, Q Sun, DI Chasman, M Foy, L Wang, J Zhu, DS Siscovick, MY Tsai, DK Arnett, BM Psaty, L Djousse, YD Chen, W Tang, LC Weng, H Wu, MK Jensen, AY Chu, DR Jacobs, SS Rich, D Mozaffarian, L Steffen, EB Rimm, FB Hu, PM Ridker, M Fornage, Y Friedlander

TITLE:

Genetic loci associated with circulating levels of very long-chain saturated fatty acids.

JOURNAL:

Journal of lipid research Jan 2015, Vol 56, pp. 176-84

ABSTRACT:

Very long-chain saturated fatty acids (VLSFAs) are saturated fatty acids with 20 or more carbons. In contrast to the more abundant saturated fatty acids, such as palmitic acid, there is growing evidence that circulating VLSFAs may have beneficial biological properties. Whether genetic factors influence circulating levels of VLSFAs is not known. We investigated the association of common genetic variation with plasma phospholipid/erythrocyte levels of three VLSFAs by performing genome-wide association studies in seven population-based cohorts comprising 10,129 subjects of European ancestry. We observed associations of circulating VLSFA concentrations with common variants in two genes, serine palmitoyl-transferase long-chain base subunit 3 (SPTLC3), a gene involved in the rate-limiting step of de novo sphingolipid synthesis, and ceramide synthase 4 (CERS4). The SPTLC3 variant at rs680379 was associated with higher arachidic acid (20:0 , P = 5.81 × 10(-13)). The CERS4 variant at rs2100944 was associated with higher levels of 20:0 (P = 2.65 × 10(-40)) and in analyses that adjusted for 20:0, with lower levels of behenic acid (P = 4.22 × 10(-26)) and lignoceric acid (P = 3.20 × 10(-21)). These novel associations suggest an inter-relationship of circulating VLSFAs and sphingolipid synthesis. PUBMED: 25378659
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