DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Dehydroepiandrosterone sulphate levels. The EFO term hormone measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: hormone measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

G Zhai, A Teumer, L Stolk, JR Perry, L Vandenput, AD Coviello, A Koster, JT Bell, S Bhasin, J Eriksson, A Eriksson, F Ernst, L Ferrucci, TM Frayling, D Glass, E Grundberg, R Haring, AK Hedman, A Hofman, DP Kiel, HK Kroemer, Y Liu, KL Lunetta, M Maggio, M Lorentzon, M Mangino, D Melzer, I Miljkovic, A Nica, BW Penninx, RS Vasan, F Rivadeneira, KS Small, N Soranzo, AG Uitterlinden, H Völzke, SG Wilson, L Xi, WV Zhuang, TB Harris, JM Murabito, C Ohlsson, A Murray, FH de Jong, TD Spector, H Wallaschofski

TITLE:

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.

JOURNAL:

PLoS genetics Apr 2011, Vol 7, pp. e1002025

ABSTRACT:

Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands--yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15 × 10(-36)), SULT2A1 (rs2637125; p =  2.61 × 10(-19)), ARPC1A (rs740160; p =  1.56 × 10(-16)), TRIM4 (rs17277546; p =  4.50 × 10(-11)), BMF (rs7181230; p = 5.44 × 10(-11)), HHEX (rs2497306; p =  4.64 × 10(-9)), BCL2L11 (rs6738028; p = 1.72 × 10(-8)), and CYP2C9 (rs2185570; p = 2.29 × 10(-8)). These genes are associated with type 2 diabetes, lymphoma, actin filament assembly, drug and xenobiotic metabolism, and zinc finger proteins. Several SNPs were associated with changes in gene expression levels, and the related genes are connected to biological pathways linking DHEAS with ageing. This study provides much needed insight into the function of DHEAS. PUBMED: 21533175
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