DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Fibrinogen levels. The EFO term fibrinogen measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: fibrinogen measurement

SCORE TYPE:

P-Value

THRESHOLD:

<= 0.05

GENES IN THRESHOLD:

45

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

PS de Vries, DI Chasman, M Sabater-Lleal, MH Chen, JE Huffman, M Steri, W Tang, A Teumer, RE Marioni, V Grossmann, JJ Hottenga, S Trompet, M Müller-Nurasyid, JH Zhao, JA Brody, ME Kleber, X Guo, JJ Wang, PL Auer, JR Attia, LR Yanek, TS Ahluwalia, J Lahti, C Venturini, T Tanaka, LF Bielak, PK Joshi, A Rocanin-Arjo, I Kolcic, P Navarro, LM Rose, C Oldmeadow, H Riess, J Mazur, S Basu, A Goel, Q Yang, M Ghanbari, G Willemsen, A Rumley, E Fiorillo, AJ de Craen, A Grotevendt, R Scott, KD Taylor, GE Delgado, J Yao, A Kifley, C Kooperberg, R Qayyum, LM Lopez, TL Berentzen, K Räikkönen, M Mangino, S Bandinelli, PA Peyser, S Wild, DA Trégouët, AF Wright, J Marten, T Zemunik, AC Morrison, B Sennblad, G Tofler, MP de Maat, EJ de Geus, GD Lowe, M Zoledziewska, N Sattar, H Binder, U Völker, M Waldenberger, KT Khaw, B Mcknight, J Huang, NS Jenny, EG Holliday, L Qi, MG Mcevoy, DM Becker, JM Starr, AP Sarin, PG Hysi, DG Hernandez, MA Jhun, H Campbell, A Hamsten, F Rivadeneira, WL Mcardle, PE Slagboom, T Zeller, W Koenig, BM Psaty, T Haritunians, J Liu, A Palotie, AG Uitterlinden, DJ Stott, A Hofman, OH Franco, O Polasek, I Rudan, PE Morange, JF Wilson, SL Kardia, L Ferrucci, TD Spector, JG Eriksson, T Hansen, IJ Deary, LC Becker, RJ Scott, P Mitchell, W März, NJ Wareham, A Peters, A Greinacher, PS Wild, JW Jukema, DI Boomsma, C Hayward, F Cucca, R Tracy, H Watkins, AP Reiner, AR Folsom, PM Ridker, CJ O'Donnell, NL Smith, DP Strachan, A Dehghan

TITLE:

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.

JOURNAL:

Human molecular genetics Jan 2016, Vol 25, pp. 358-70

ABSTRACT:

Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci; of which, 18 were newly identified. There were no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration. PUBMED: 26561523
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