GeneSet Information

Tier I GS268335 • GWAS Catalog Data for Alzheimers disease in 6,688 European ancestry cases, 13,685 European ancestry controls

DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Alzheimer's disease. The EFO term Alzheimers disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Alzheimers disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

P Hollingworth, D Harold, R Sims, A Gerrish, JC Lambert, MM Carrasquillo, R Abraham, ML Hamshere, JS Pahwa, V Moskvina, K Dowzell, N Jones, A Stretton, C Thomas, A Richards, D Ivanov, C Widdowson, J Chapman, S Lovestone, J Powell, P Proitsi, MK Lupton, C Brayne, DC Rubinsztein, M Gill, B Lawlor, A Lynch, KS Brown, PA Passmore, D Craig, B McGuinness, S Todd, C Holmes, D Mann, AD Smith, H Beaumont, D Warden, G Wilcock, S Love, PG Kehoe, NM Hooper, ER Vardy, J Hardy, S Mead, NC Fox, M Rossor, J Collinge, W Maier, F Jessen, E Rüther, B Schürmann, R Heun, H Kölsch, H van den Bussche, I Heuser, J Kornhuber, J Wiltfang, M Dichgans, L Frölich, H Hampel, J Gallacher, M Hüll, D Rujescu, I Giegling, AM Goate, JS Kauwe, C Cruchaga, P Nowotny, JC Morris, K Mayo, K Sleegers, K Bettens, S Engelborghs, PP De Deyn, C Van Broeckhoven, G Livingston, NJ Bass, H Gurling, A McQuillin, R Gwilliam, P Deloukas, A Al-Chalabi, CE Shaw, M Tsolaki, AB Singleton, R Guerreiro, TW Mühleisen, MM Nöthen, S Moebus, KH Jöckel, N Klopp, HE Wichmann, VS Pankratz, SB Sando, JO Aasly, M Barcikowska, ZK Wszolek, DW Dickson, NR Graff-Radford, RC Petersen, CM van Duijn, MM Breteler, MA Ikram, AL DeStefano, AL Fitzpatrick, O Lopez, LJ Launer, S Seshadri, C Berr, D Campion, J Epelbaum, JF Dartigues, C Tzourio, A Alpérovitch, M Lathrop, TM Feulner, P Friedrich, C Riehle, M Krawczak, S Schreiber, M Mayhaus, S Nicolhaus, S Wagenpfeil, S Steinberg, H Stefansson, K Stefansson, J Snaedal, S Björnsson, PV Jonsson, V Chouraki, B Genier-Boley, M Hiltunen, H Soininen, O Combarros, D Zelenika, M Delepine, MJ Bullido, F Pasquier, I Mateo, A Frank-Garcia, E Porcellini, O Hanon, E Coto, V Alvarez, P Bosco, G Siciliano, M Mancuso, F Panza, V Solfrizzi, B Nacmias, S Sorbi, P Bossù, P Piccardi, B Arosio, G Annoni, D Seripa, A Pilotto, E Scarpini, D Galimberti, A Brice, D Hannequin, F Licastro, L Jones, PA Holmans, T Jonsson, M Riemenschneider, K Morgan, SG Younkin, MJ Owen, M O'Donovan, P Amouyel, J Williams

TITLE:

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

JOURNAL:

Nature genetics May 2011, Vol 43, pp. 429-35

ABSTRACT:

We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ≤ 1 × 10(-5). We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)). PUBMED: 21460840
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