DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Alzheimer's disease (late onset). The EFO term Alzheimers disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Alzheimers disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

AC Naj, G Jun, GW Beecham, LS Wang, BN Vardarajan, J Buros, PJ Gallins, JD Buxbaum, GP Jarvik, PK Crane, EB Larson, TD Bird, BF Boeve, NR Graff-Radford, PL De Jager, D Evans, JA Schneider, MM Carrasquillo, N Ertekin-Taner, SG Younkin, C Cruchaga, JS Kauwe, P Nowotny, P Kramer, J Hardy, MJ Huentelman, AJ Myers, MM Barmada, FY Demirci, CT Baldwin, RC Green, E Rogaeva, P St George-Hyslop, SE Arnold, R Barber, T Beach, EH Bigio, JD Bowen, A Boxer, JR Burke, NJ Cairns, CS Carlson, RM Carney, SL Carroll, HC Chui, DG Clark, J Corneveaux, CW Cotman, JL Cummings, C DeCarli, ST DeKosky, R Diaz-Arrastia, M Dick, DW Dickson, WG Ellis, KM Faber, KB Fallon, MR Farlow, S Ferris, MP Frosch, DR Galasko, M Ganguli, M Gearing, DH Geschwind, B Ghetti, JR Gilbert, S Gilman, B Giordani, JD Glass, JH Growdon, RL Hamilton, LE Harrell, E Head, LS Honig, CM Hulette, BT Hyman, GA Jicha, LW Jin, N Johnson, J Karlawish, A Karydas, JA Kaye, R Kim, EH Koo, NW Kowall, JJ Lah, AI Levey, AP Lieberman, OL Lopez, WJ Mack, DC Marson, F Martiniuk, DC Mash, E Masliah, WC McCormick, SM McCurry, AN McDavid, AC McKee, M Mesulam, BL Miller, CA Miller, JW Miller, JE Parisi, DP Perl, E Peskind, RC Petersen, WW Poon, JF Quinn, RA Rajbhandary, M Raskind, B Reisberg, JM Ringman, ED Roberson, RN Rosenberg, M Sano, LS Schneider, W Seeley, ML Shelanski, MA Slifer, CD Smith, JA Sonnen, S Spina, RA Stern, RE Tanzi, JQ Trojanowski, JC Troncoso, VM Van Deerlin, HV Vinters, JP Vonsattel, S Weintraub, KA Welsh-Bohmer, J Williamson, RL Woltjer, LB Cantwell, BA Dombroski, D Beekly, KL Lunetta, ER Martin, MI Kamboh, AJ Saykin, EM Reiman, DA Bennett, JC Morris, TJ Montine, AM Goate, D Blacker, DW Tsuang, H Hakonarson, WA Kukull, TM Foroud, JL Haines, R Mayeux, MA Pericak-Vance, LA Farrer, GD Schellenberg

TITLE:

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

JOURNAL:

Nature genetics May 2011, Vol 43, pp. 436-41

ABSTRACT:

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (P(M)) = 1.7 × 10(-9), joint analysis P (P(J)) = 1.7 × 10(-9); stages 1, 2 and 3, P(M) = 8.2 × 10(-12)), CD2AP (rs9349407; stages 1, 2 and 3, P(M) = 8.6 × 10(-9)), EPHA1 (rs11767557; stages 1, 2 and 3, P(M) = 6.0 × 10(-10)) and CD33 (rs3865444; stages 1, 2 and 3, P(M) = 1.6 × 10(-9)). We also replicated previous associations at CR1 (rs6701713; P(M) = 4.6 × 10(-10), P(J) = 5.2 × 10(-11)), CLU (rs1532278; P(M) = 8.3 × 10(-8), P(J) = 1.9 × 10(-8)), BIN1 (rs7561528; P(M) = 4.0 × 10(-14), P(J) = 5.2 × 10(-14)) and PICALM (rs561655; P(M) = 7.0 × 10(-11), P(J) = 1.0 × 10(-10)), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility. PUBMED: 21460841
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