DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Colorectal cancer. The EFO term colorectal cancer was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: colorectal cancer

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

H Wang, T Burnett, S Kono, CA Haiman, M Iwasaki, LR Wilkens, LW Loo, D Van Den Berg, LN Kolonel, BE Henderson, TO Keku, RS Sandler, LB Signorello, WJ Blot, PA Newcomb, M Pande, CI Amos, DW West, S Bézieau, SI Berndt, BW Zanke, L Hsu, NM Lindor, RW Haile, JL Hopper, MA Jenkins, S Gallinger, G Casey, SL Stenzel, FR Schumacher, U Peters, SB Gruber, S Tsugane, DO Stram, L Le Marchand

TITLE:

Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.

JOURNAL:

Nature communications Aug 2014, Vol 5, pp. 4613

ABSTRACT:

The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P<5 × 10(-8)) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4 × 10(-9)), providing additional insight into the aetiology of CRC and highlighting the value of association mapping in diverse populations. PUBMED: 25105248
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