DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Coronary heart disease. The EFO term coronary heart disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: coronary heart disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

H Schunkert, IR König, S Kathiresan, MP Reilly, TL Assimes, H Holm, M Preuss, AF Stewart, M Barbalic, C Gieger, D Absher, Z Aherrahrou, H Allayee, D Altshuler, SS Anand, K Andersen, JL Anderson, D Ardissino, SG Ball, AJ Balmforth, TA Barnes, DM Becker, LC Becker, K Berger, JC Bis, SM Boekholdt, E Boerwinkle, PS Braund, MJ Brown, MS Burnett, I Buysschaert, JF Carlquist, L Chen, S Cichon, V Codd, RW Davies, G Dedoussis, A Dehghan, S Demissie, JM Devaney, P Diemert, R Do, A Doering, S Eifert, NE Mokhtari, SG Ellis, R Elosua, JC Engert, SE Epstein, U de Faire, M Fischer, AR Folsom, J Freyer, B Gigante, D Girelli, S Gretarsdottir, V Gudnason, JR Gulcher, E Halperin, N Hammond, SL Hazen, A Hofman, BD Horne, T Illig, C Iribarren, GT Jones, JW Jukema, MA Kaiser, LM Kaplan, JJ Kastelein, KT Khaw, JW Knowles, G Kolovou, A Kong, R Laaksonen, D Lambrechts, K Leander, G Lettre, M Li, W Lieb, C Loley, AJ Lotery, PM Mannucci, S Maouche, N Martinelli, PP McKeown, C Meisinger, T Meitinger, O Melander, PA Merlini, V Mooser, T Morgan, TW Mühleisen, JB Muhlestein, T Münzel, K Musunuru, J Nahrstaedt, CP Nelson, MM Nöthen, O Olivieri, RS Patel, CC Patterson, A Peters, F Peyvandi, L Qu, AA Quyyumi, DJ Rader, LS Rallidis, C Rice, FR Rosendaal, D Rubin, V Salomaa, ML Sampietro, MS Sandhu, E Schadt, A Schäfer, A Schillert, S Schreiber, J Schrezenmeir, SM Schwartz, DS Siscovick, M Sivananthan, S Sivapalaratnam, A Smith, TB Smith, JD Snoep, N Soranzo, JA Spertus, K Stark, K Stirrups, M Stoll, WH Tang, S Tennstedt, G Thorgeirsson, G Thorleifsson, M Tomaszewski, AG Uitterlinden, AM van Rij, BF Voight, NJ Wareham, GA Wells, HE Wichmann, PS Wild, C Willenborg, JC Witteman, BJ Wright, S Ye, T Zeller, A Ziegler, F Cambien, AH Goodall, LA Cupples, T Quertermous, W März, C Hengstenberg, S Blankenberg, WH Ouwehand, AS Hall, P Deloukas, JR Thompson, K Stefansson, R Roberts, U Thorsteinsdottir, CJ O'Donnell, R McPherson, J Erdmann, NJ Samani

TITLE:

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

JOURNAL:

Nature genetics Mar 2011, Vol 43, pp. 333-8

ABSTRACT:

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10⁻⁸ and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits. PUBMED: 21378990
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