DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Pancreatic cancer. The EFO term pancreatic carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: pancreatic carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

GM Petersen, L Amundadottir, CS Fuchs, P Kraft, RZ Stolzenberg-Solomon, KB Jacobs, AA Arslan, HB Bueno-de-Mesquita, S Gallinger, M Gross, K Helzlsouer, EA Holly, EJ Jacobs, AP Klein, A LaCroix, D Li, MT Mandelson, SH Olson, HA Risch, W Zheng, D Albanes, WR Bamlet, CD Berg, MC Boutron-Ruault, JE Buring, PM Bracci, F Canzian, S Clipp, M Cotterchio, M de Andrade, EJ Duell, JM Gaziano, EL Giovannucci, M Goggins, G Hallmans, SE Hankinson, M Hassan, B Howard, DJ Hunter, A Hutchinson, M Jenab, R Kaaks, C Kooperberg, V Krogh, RC Kurtz, SM Lynch, RR McWilliams, JB Mendelsohn, DS Michaud, H Parikh, AV Patel, PH Peeters, A Rajkovic, E Riboli, L Rodriguez, D Seminara, XO Shu, G Thomas, A Tjønneland, GS Tobias, D Trichopoulos, SK Van Den Eeden, J Virtamo, J Wactawski-Wende, Z Wang, BM Wolpin, H Yu, K Yu, A Zeleniuch-Jacquotte, JF Fraumeni, RN Hoover, P Hartge, SJ Chanock

TITLE:

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.

JOURNAL:

Nature genetics Mar 2010, Vol 42, pp. 224-8

ABSTRACT:

We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies. PUBMED: 20101243
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