DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Hodgkin's lymphoma. The EFO term Hodgkins lymphoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Hodgkins lymphoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

W Cozen, MN Timofeeva, D Li, A Diepstra, D Hazelett, M Delahaye-Sourdeix, CK Edlund, L Franke, K Rostgaard, DJ Van Den Berg, VK Cortessis, KE Smedby, SL Glaser, HJ Westra, LL Robison, TM Mack, H Ghesquieres, AE Hwang, A Nieters, S de Sanjose, T Lightfoot, N Becker, M Maynadie, L Foretova, E Roman, Y Benavente, KA Rand, BN Nathwani, B Glimelius, A Staines, P Boffetta, BK Link, L Kiemeney, SM Ansell, S Bhatia, LC Strong, P Galan, L Vatten, TM Habermann, EJ Duell, A Lake, RN Veenstra, L Visser, Y Liu, KY Urayama, D Montgomery, V Gaborieau, LM Weiss, G Byrnes, M Lathrop, P Cocco, T Best, AD Skol, HO Adami, M Melbye, JR Cerhan, A Gallagher, GM Taylor, SL Slager, P Brennan, GA Coetzee, DV Conti, K Onel, RF Jarrett, H Hjalgrim, A van den Berg, JD McKay

TITLE:

A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.

JOURNAL:

Nature communications Jun 2014, Vol 5, pp. 3856

ABSTRACT:

Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95% confidence interval (95% CI) = 0.76-0.86, P(combined) = 3.5 × 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B- and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk. PUBMED: 24920014
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