DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Sjögren's syndrome. The EFO term Sjogren syndrome was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Sjogren syndrome

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Y Li, K Zhang, H Chen, F Sun, J Xu, Z Wu, P Li, L Zhang, Y Du, H Luan, X Li, L Wu, H Li, H Wu, X Li, X Li, X Zhang, L Gong, L Dai, L Sun, X Zuo, J Xu, H Gong, Z Li, S Tong, M Wu, X Li, W Xiao, G Wang, P Zhu, M Shen, S Liu, D Zhao, W Liu, Y Wang, C Huang, Q Jiang, G Liu, B Liu, S Hu, W Zhang, Z Zhang, X You, M Li, W Hao, C Zhao, X Leng, L Bi, Y Wang, F Zhang, Q Shi, W Qi, X Zhang, Y Jia, J Su, Q Li, Y Hou, Q Wu, D Xu, W Zheng, M Zhang, Q Wang, Y Fei, X Zhang, J Li, Y Jiang, X Tian, L Zhao, L Wang, B Zhou, Y Li, Y Zhao, X Zeng, J Ott, J Wang, F Zhang

TITLE:

A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23.

JOURNAL:

Nature genetics Nov 2013, Vol 45, pp. 1361-5

ABSTRACT:

Primary Sjögren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjögren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjögren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 556,134 autosomal SNPs in 542 cases and 1,050 controls. We then validated promising associations in 2 replication stages comprising 1,303 cases and 2,727 controls. The combined analysis identified GTF2I at 7q11.23 (rs117026326: Pcombined = 1.31 × 10(-53), combined odds ratio (ORcombined) = 2.20) as a new susceptibility locus for primary Sjögren's syndrome. Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC). Fine mapping of the region around GTF2I showed that rs117026326 in GTF2I had the most significant association, with associated SNPs extending from GTF2I to GTF2IRD1-GTF2I. PUBMED: 24097066
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