DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Coronary heart disease. The EFO term coronary heart disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: coronary heart disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

RW Davies, GA Wells, AF Stewart, J Erdmann, SH Shah, JF Ferguson, AS Hall, SS Anand, MS Burnett, SE Epstein, S Dandona, L Chen, J Nahrstaedt, C Loley, IR König, WE Kraus, CB Granger, JC Engert, C Hengstenberg, HE Wichmann, S Schreiber, WH Tang, SG Ellis, DJ Rader, SL Hazen, MP Reilly, NJ Samani, H Schunkert, R Roberts, R McPherson

TITLE:

A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.

JOURNAL:

Circulation. Cardiovascular genetics Apr 2012, Vol 5, pp. 217-25

ABSTRACT:

Recent genome-wide association studies (GWAS) have identified several novel loci that reproducibly associate with coronary artery disease (CAD) and/or myocardial infarction risk. However, known common CAD risk variants explain only 10% of the predicted genetic heritability of the disease, suggesting that important genetic signals remain to be discovered. PUBMED: 22319020
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