DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Parkinson's disease. The EFO term Parkinson's disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Parkinson's disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

J Simón-Sánchez, C Schulte, JM Bras, M Sharma, JR Gibbs, D Berg, C Paisan-Ruiz, P Lichtner, SW Scholz, DG Hernandez, R Krüger, M Federoff, C Klein, A Goate, J Perlmutter, M Bonin, MA Nalls, T Illig, C Gieger, H Houlden, M Steffens, MS Okun, BA Racette, MR Cookson, KD Foote, HH Fernandez, BJ Traynor, S Schreiber, S Arepalli, R Zonozi, K Gwinn, M van der Brug, G Lopez, SJ Chanock, A Schatzkin, Y Park, A Hollenbeck, J Gao, X Huang, NW Wood, D Lorenz, G Deuschl, H Chen, O Riess, JA Hardy, AB Singleton, T Gasser

TITLE:

Genome-wide association study reveals genetic risk underlying Parkinson's disease.

JOURNAL:

Nature genetics Dec 2009, Vol 41, pp. 1308-12

ABSTRACT:

We performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, we observed two strong association signals, one in the gene encoding alpha-synuclein (SNCA; rs2736990, OR = 1.23, P = 2.24 x 10(-16)) and another at the MAPT locus (rs393152, OR = 0.77, P = 1.95 x 10(-16)). We exchanged data with colleagues performing a GWAS in Japanese PD cases. Association to PD at SNCA was replicated in the Japanese GWAS, confirming this as a major risk locus across populations. We replicated the effect of a new locus detected in the Japanese cohort (PARK16, rs823128, OR = 0.66, P = 7.29 x 10(-8)) and provide supporting evidence that common variation around LRRK2 modulates risk for PD (rs1491923, OR = 1.14, P = 1.55 x 10(-5)). These data demonstrate an unequivocal role for common genetic variants in the etiology of typical PD and suggest population-specific genetic heterogeneity in this disease. PUBMED: 19915575
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