DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Crohn's disease. The EFO term Crohn's disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Crohn's disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

A Julià, E Domènech, E Ricart, R Tortosa, V García-Sánchez, JP Gisbert, P Nos Mateu, A Gutiérrez, F Gomollón, JL Mendoza, E Garcia-Planella, M Barreiro-de Acosta, F Muñoz, M Vera, C Saro, M Esteve, M Andreu, A Alonso, M López-Lasanta, L Codó, JL Gelpí, AC García-Montero, J Bertranpetit, D Absher, J Panés, S Marsal

TITLE:

A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.

JOURNAL:

Gut Oct 2013, Vol 62, pp. 1440-5

ABSTRACT:

Genome-wide association studies (GWAS) have identified multiple risk loci for Crohn's disease (CD). However, the cumulative risk exerted by these loci is low, and the likelihood that additional, as-yet undiscovered loci contribute to the risk of CD is very high. We performed a GWAS on a southern European population to identify new CD risk loci. PUBMED: 22936669
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