DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Cannabis dependence. The EFO term marijuana dependence was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: marijuana dependence

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

A Agrawal, MT Lynskey, A Hinrichs, R Grucza, SF Saccone, R Krueger, R Neuman, W Howells, S Fisher, L Fox, R Cloninger, DM Dick, KF Doheny, HJ Edenberg, AM Goate, V Hesselbrock, E Johnson, J Kramer, S Kuperman, JI Nurnberger, E Pugh, M Schuckit, J Tischfield, JP Rice, KK Bucholz, LJ Bierut

TITLE:

A genome-wide association study of DSM-IV cannabis dependence.

JOURNAL:

Addiction biology Jul 2011, Vol 16, pp. 514-8

ABSTRACT:

Despite twin studies showing that 50-70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted using logistic regression in PLINK. None of the 948 142 single nucleotide polymorphisms met genome-wide significance (P at E-8). The lowest P values were obtained for polymorphisms on chromosome 17 (rs1019238 and rs1431318, P values at E-7) in the ANKFN1 gene. While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence. PUBMED: 21668797
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