DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Helicobacter pylori serologic status. The EFO term anti-Heliobacter pylori serum IgG measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: anti-Heliobacter pylori serum IgG measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

J Mayerle, CM den Hoed, C Schurmann, L Stolk, G Homuth, MJ Peters, LG Capelle, K Zimmermann, F Rivadeneira, S Gruska, H Völzke, AC de Vries, U Völker, A Teumer, JB van Meurs, I Steinmetz, M Nauck, F Ernst, FU Weiss, A Hofman, M Zenker, HK Kroemer, H Prokisch, AG Uitterlinden, MM Lerch, EJ Kuipers, E Kuipers

TITLE:

Identification of genetic loci associated with Helicobacter pylori serologic status.

JOURNAL:

JAMA May 2013, Vol 309, pp. 1912-20

ABSTRACT:

Helicobacter pylori is a major cause of gastritis and gastroduodenal ulcer disease and can cause cancer. H. pylori prevalence is as high as 90% in some developing countries but 10% of a given population is never colonized, regardless of exposure. Genetic factors are hypothesized to confer H. pylori susceptibility. PUBMED: 23652523
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