DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Primary biliary cirrhosis. The EFO term biliary liver cirrhosis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: biliary liver cirrhosis

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

X Liu, P Invernizzi, Y Lu, R Kosoy, Y Lu, I Bianchi, M Podda, C Xu, G Xie, F Macciardi, C Selmi, S Lupoli, R Shigeta, M Ransom, A Lleo, AT Lee, AL Mason, RP Myers, KM Peltekian, CN Ghent, F Bernuzzi, M Zuin, F Rosina, E Borghesio, A Floreani, R Lazzari, G Niro, A Andriulli, L Muratori, P Muratori, PL Almasio, P Andreone, M Margotti, M Brunetto, B Coco, D Alvaro, MC Bragazzi, F Marra, A Pisano, C Rigamonti, M Colombo, M Marzioni, A Benedetti, L Fabris, M Strazzabosco, P Portincasa, VO Palmieri, C Tiribelli, L Croce, S Bruno, S Rossi, M Vinci, C Prisco, A Mattalia, P Toniutto, A Picciotto, A Galli, C Ferrari, S Colombo, G Casella, L Morini, N Caporaso, A Colli, G Spinzi, R Montanari, PK Gregersen, EJ Heathcote, GM Hirschfield, KA Siminovitch, CI Amos, ME Gershwin, MF Seldin

TITLE:

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

JOURNAL:

Nature genetics Aug 2010, Vol 42, pp. 658-60

ABSTRACT:

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38). PUBMED: 20639880
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