DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Rapid functional decline in sporadic amyotrophic lateral sclerosis. The EFO term functional decline measurement, sporadic amyotrophic lateral sclerosis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: functional decline measurement, sporadic amyotrophic lateral sclerosis

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

H Watanabe, N Atsuta, A Hirakawa, R Nakamura, M Nakatochi, S Ishigaki, A Iida, S Ikegawa, M Kubo, D Yokoi, H Watanabe, M Ito, M Katsuno, Y Izumi, M Morita, K Kanai, A Taniguchi, I Aiba, K Abe, K Mizoguchi, M Oda, O Kano, K Okamoto, S Kuwabara, K Hasegawa, T Imai, A Kawata, M Aoki, S Tsuji, K Nakashima, R Kaji, G Sobue

TITLE:

A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN.

JOURNAL:

Journal of neurology, neurosurgery, and psychiatry Aug 2016, Vol 87, pp. 851-8

ABSTRACT:

To classify the patterns of functional decline in patients with sporadic amyotrophic lateral sclerosis (ALS) and explore the genetic backgrounds that modified these patterns. PUBMED: 26746183
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