DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Migraine. The EFO term migraine disorder was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: migraine disorder

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

T Freilinger, V Anttila, B de Vries, R Malik, M Kallela, GM Terwindt, P Pozo-Rosich, B Winsvold, DR Nyholt, WP van Oosterhout, V Artto, U Todt, E Hämäläinen, J Fernández-Morales, MA Louter, MA Kaunisto, J Schoenen, O Raitakari, T Lehtimäki, M Vila-Pueyo, H Göbel, E Wichmann, C Sintas, AG Uitterlinden, A Hofman, F Rivadeneira, A Heinze, E Tronvik, CM van Duijn, J Kaprio, B Cormand, M Wessman, RR Frants, T Meitinger, B Müller-Myhsok, JA Zwart, M Färkkilä, A Macaya, MD Ferrari, C Kubisch, A Palotie, M Dichgans, AM van den Maagdenberg

TITLE:

Genome-wide association analysis identifies susceptibility loci for migraine without aura.

JOURNAL:

Nature genetics Jun 2012, Vol 44, pp. 777-82

ABSTRACT:

Migraine without aura is the most common form of migraine, characterized by recurrent disabling headache and associated autonomic symptoms. To identify common genetic variants associated with this migraine type, we analyzed genome-wide association data of 2,326 clinic-based German and Dutch individuals with migraine without aura and 4,580 population-matched controls. We selected SNPs from 12 loci with 2 or more SNPs associated with P values of <1 × 10(-5) for replication testing in 2,508 individuals with migraine without aura and 2,652 controls. SNPs at two of these loci showed convincing replication: at 1q22 (in MEF2D; replication P = 4.9 × 10(-4); combined P = 7.06 × 10(-11)) and at 3p24 (near TGFBR2; replication P = 1.0 × 10(-4); combined P = 1.17 × 10(-9)). In addition, SNPs at the PHACTR1 and ASTN2 loci showed suggestive evidence of replication (P = 0.01; combined P = 3.20 × 10(-8) and P = 0.02; combined P = 3.86 × 10(-8), respectively). We also replicated associations at two previously reported migraine loci in or near TRPM8 and LRP1. This study identifies the first susceptibility loci for migraine without aura, thereby expanding our knowledge of this debilitating neurological disorder. PUBMED: 22683712
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