DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Hair morphology. The EFO term hair morphology was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: hair morphology

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

SE Medland, DR Nyholt, JN Painter, BP McEvoy, AF McRae, G Zhu, SD Gordon, MA Ferreira, MJ Wright, AK Henders, MJ Campbell, DL Duffy, NK Hansell, S Macgregor, WS Slutske, AC Heath, GW Montgomery, NG Martin

TITLE:

Common variants in the trichohyalin gene are associated with straight hair in Europeans.

JOURNAL:

American journal of human genetics Nov 2009, Vol 85, pp. 750-5

ABSTRACT:

Hair morphology is highly differentiated between populations and among people of European ancestry. Whereas hair morphology in East Asian populations has been studied extensively, relatively little is known about the genetics of this trait in Europeans. We performed a genome-wide association scan for hair morphology (straight, wavy, curly) in three Australian samples of European descent. All three samples showed evidence of association implicating the Trichohyalin gene (TCHH), which is expressed in the developing inner root sheath of the hair follicle, and explaining approximately 6% of variance (p=1.5x10(-31)). These variants are at their highest frequency in Northern Europeans, paralleling the distribution of the straight-hair EDAR variant in Asian populations. PUBMED: 19896111
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