DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Pancreatic cancer. The EFO term pancreatic carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: pancreatic carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

BM Wolpin, C Rizzato, P Kraft, C Kooperberg, GM Petersen, Z Wang, AA Arslan, L Beane-Freeman, PM Bracci, J Buring, F Canzian, EJ Duell, S Gallinger, GG Giles, GE Goodman, PJ Goodman, EJ Jacobs, A Kamineni, AP Klein, LN Kolonel, MH Kulke, D Li, N Malats, SH Olson, HA Risch, HD Sesso, K Visvanathan, E White, W Zheng, CC Abnet, D Albanes, G Andreotti, MA Austin, R Barfield, D Basso, SI Berndt, MC Boutron-Ruault, M Brotzman, MW Büchler, HB Bueno-de-Mesquita, P Bugert, L Burdette, D Campa, NE Caporaso, G Capurso, C Chung, M Cotterchio, E Costello, J Elena, N Funel, JM Gaziano, NA Giese, EL Giovannucci, M Goggins, MJ Gorman, M Gross, CA Haiman, M Hassan, KJ Helzlsouer, BE Henderson, EA Holly, N Hu, DJ Hunter, F Innocenti, M Jenab, R Kaaks, TJ Key, KT Khaw, EA Klein, M Kogevinas, V Krogh, J Kupcinskas, RC Kurtz, A LaCroix, MT Landi, S Landi, L Le Marchand, A Mambrini, S Mannisto, RL Milne, Y Nakamura, AL Oberg, K Owzar, AV Patel, PH Peeters, U Peters, R Pezzilli, A Piepoli, M Porta, FX Real, E Riboli, N Rothman, A Scarpa, XO Shu, DT Silverman, P Soucek, M Sund, R Talar-Wojnarowska, PR Taylor, GE Theodoropoulos, M Thornquist, A Tjønneland, GS Tobias, D Trichopoulos, P Vodicka, J Wactawski-Wende, N Wentzensen, C Wu, H Yu, K Yu, A Zeleniuch-Jacquotte, R Hoover, P Hartge, C Fuchs, SJ Chanock, RS Stolzenberg-Solomon, LT Amundadottir

TITLE:

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.

JOURNAL:

Nature genetics Sep 2014, Vol 46, pp. 994-1000

ABSTRACT:

We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies. PUBMED: 25086665
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