DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was PR interval. The EFO term PR interval was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: PR interval

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

A Pfeufer, C van Noord, KD Marciante, DE Arking, MG Larson, AV Smith, KV Tarasov, M Müller, N Sotoodehnia, MF Sinner, GC Verwoert, M Li, WH Kao, A Köttgen, J Coresh, JC Bis, BM Psaty, K Rice, JI Rotter, F Rivadeneira, A Hofman, JA Kors, BH Stricker, AG Uitterlinden, CM van Duijn, BM Beckmann, W Sauter, C Gieger, SA Lubitz, C Newton-Cheh, TJ Wang, JW Magnani, RB Schnabel, MK Chung, J Barnard, JD Smith, DR Van Wagoner, RS Vasan, T Aspelund, G Eiriksdottir, TB Harris, LJ Launer, SS Najjar, E Lakatta, D Schlessinger, M Uda, GR Abecasis, B Müller-Myhsok, GB Ehret, E Boerwinkle, A Chakravarti, EZ Soliman, KL Lunetta, S Perz, HE Wichmann, T Meitinger, D Levy, V Gudnason, PT Ellinor, S Sanna, S Kääb, JC Witteman, A Alonso, EJ Benjamin, SR Heckbert

TITLE:

Genome-wide association study of PR interval.

JOURNAL:

Nature genetics Feb 2010, Vol 42, pp. 153-9

ABSTRACT:

The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-analysis of genome-wide association studies for PR interval from seven population-based European studies in the CHARGE Consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam Study, and SardiNIA (N = 28,517). We identified nine loci associated with PR interval at P < 5 x 10(-8). At the 3p22.2 locus, we observed two independent associations in voltage-gated sodium channel genes, SCN10A and SCN5A. Six of the loci were near cardiac developmental genes, including CAV1-CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5-TBX3, providing pathophysiologically interesting candidate genes. Five of the loci, SCN5A, SCN10A, NKX2-5, CAV1-CAV2, and SOX5, were also associated with atrial fibrillation (N = 5,741 cases, P < 0.0056). This suggests a role for common variation in ion channel and developmental genes in atrial and atrioventricular conduction as well as in susceptibility to atrial fibrillation. PUBMED: 20062060
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