DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Parkinson's disease. The EFO term Parkinson's disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Parkinson's disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

MA Nalls, N Pankratz, CM Lill, CB Do, DG Hernandez, M Saad, AL DeStefano, E Kara, J Bras, M Sharma, C Schulte, MF Keller, S Arepalli, C Letson, C Edsall, H Stefansson, X Liu, H Pliner, JH Lee, R Cheng, MA Ikram, JP Ioannidis, GM Hadjigeorgiou, JC Bis, M Martinez, JS Perlmutter, A Goate, K Marder, B Fiske, M Sutherland, G Xiromerisiou, RH Myers, LN Clark, K Stefansson, JA Hardy, P Heutink, H Chen, NW Wood, H Houlden, H Payami, A Brice, WK Scott, T Gasser, L Bertram, N Eriksson, T Foroud, AB Singleton

TITLE:

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.

JOURNAL:

Nature genetics Sep 2014, Vol 46, pp. 989-93

ABSTRACT:

We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and 6 additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6 newly identified loci. Conditional analyses within loci showed that four loci, including GBA, GAK-DGKQ, SNCA and the HLA region, contain a secondary independent risk variant. In total, we identified and replicated 28 independent risk variants for Parkinson's disease across 24 loci. Although the effect of each individual locus was small, risk profile analysis showed substantial cumulative risk in a comparison of the highest and lowest quintiles of genetic risk (odds ratio (OR) = 3.31, 95% confidence interval (CI) = 2.55-4.30; P = 2 × 10(-16)). We also show six risk loci associated with proximal gene expression or DNA methylation. PUBMED: 25064009
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