DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Male-pattern baldness. The EFO term androgenetic alopecia was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: androgenetic alopecia

SCORE TYPE:

P-Value

THRESHOLD:

<= 0.05

GENES IN THRESHOLD:

4

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

FF Brockschmidt, S Heilmann, JA Ellis, S Eigelshoven, S Hanneken, C Herold, S Moebus, MA Alblas, B Lippke, N Kluck, L Priebe, FA Degenhardt, RA Jamra, C Meesters, KH Jöckel, R Erbel, S Harrap, J Schumacher, H Fröhlich, R Kruse, AM Hillmer, T Becker, MM Nöthen

TITLE:

Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness.

JOURNAL:

The British journal of dermatology Dec 2011, Vol 165, pp. 1293-302

ABSTRACT:

Male-pattern baldness (androgenetic alopecia, AGA) is the most common form of hair loss among humans. Research has shown that it is caused by genetic factors. Numerous studies have unequivocally identified two major genetic risk loci for AGA: the X-chromosomal AR/EDA2R locus, and the PAX1/FOXA2 locus on chromosome 20. PUBMED: 22032556
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