DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Lung cancer. The EFO term lung carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: lung carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JD McKay, RJ Hung, V Gaborieau, P Boffetta, A Chabrier, G Byrnes, D Zaridze, A Mukeria, N Szeszenia-Dabrowska, J Lissowska, P Rudnai, E Fabianova, D Mates, V Bencko, L Foretova, V Janout, J McLaughlin, F Shepherd, A Montpetit, S Narod, HE Krokan, F Skorpen, MB Elvestad, L Vatten, I Njølstad, T Axelsson, C Chen, G Goodman, M Barnett, MM Loomis, J Lubiñski, J Matyjasik, M Lener, D Oszutowska, J Field, T Liloglou, G Xinarianos, A Cassidy, P Vineis, F Clavel-Chapelon, D Palli, R Tumino, V Krogh, S Panico, CA González, J Ramón Quirós, C Martínez, C Navarro, E Ardanaz, N Larrañaga, KT Kham, T Key, HB Bueno-de-Mesquita, PH Peeters, A Trichopoulou, J Linseisen, H Boeing, G Hallmans, K Overvad, A Tjønneland, M Kumle, E Riboli, D Zelenika, A Boland, M Delepine, M Foglio, D Lechner, F Matsuda, H Blanche, I Gut, S Heath, M Lathrop, P Brennan

TITLE:

Lung cancer susceptibility locus at 5p15.33.

JOURNAL:

Nature genetics Dec 2008, Vol 40, pp. 1404-6

ABSTRACT:

We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the independent study series (P = 7 x 10(-5) and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology. PUBMED: 18978790
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