DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Cardiac repolarization. The EFO term TPE interval measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: TPE interval measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

A Marjamaa, L Oikarinen, K Porthan, S Ripatti, G Peloso, PA Noseworthy, M Viitasalo, MS Nieminen, L Toivonen, K Kontula, L Peltonen, AS Havulinna, A Jula, CJ O'Donnell, C Newton-Cheh, M Perola, V Salomaa

TITLE:

A common variant near the KCNJ2 gene is associated with T-peak to T-end interval.

JOURNAL:

Heart rhythm Jul 2012, Vol 9, pp. 1099-103

ABSTRACT:

T-peak to T-end (TPE) interval on the electrocardiogram is a measure of myocardial dispersion of repolarization and is associated with an increased risk of ventricular arrhythmias. The genetic factors affecting the TPE interval are largely unknown. PUBMED: 22342860
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